Prof. Alessandro Marcello
International Centre for Genetic Engineering and Biotechnology, Trieste

Alessandro Marcello is the head of the Laboratory of Molecular Virology at the International Centre for Genetic Engineering and Biotechnology in Trieste, Italy and Professor of Molecular Biology at the University of Nova Gorica, Slovenia ( A long-standing interest in host-virus interactions has driven A. Marcello's research. He strongly believes that the molecular dissection of virus-host interactions is not only relevant to the understanding of viral pathogenesis, but it is also extremely useful for the characterization of fundamental cellular processes that are exploited by the virus. Current research in the lab aims at identifying the key cellular and viral factors that control infection of viruses like the human immunodeficiency virus (HIV) and Flaviviruses such as the tick-borne encephalitis virus (TBEV) and the hepatitis C virus (HCV). He is also interested in implementing viral diagnostics for developing countries by technically supporting local scientists and by developing point-of-care portable devices in collaboration with industrial partners. Finally, the discovery of novel antiviral compounds is being pursued in collaborative international networks.

3D reconstruction of a cell infected by the tick-borne encephalitis virus showing the membranes of the ER (green) with the replication vesicles induced by the virus (yellow) and the assembled new virions (red). Image from a recent publication of the group in the Journal of Virology. The TBE virus is endemic in Europe, including Hungary.