Structure of Biological Macromolecules


DATE:
16-27 March, 1998, Miramare, Trieste, Italy

ORGANIZERS:
Sándor Pongor (ICGEB, Trieste)
Doriano Lamba (CNR,ICGEB, Trieste)
Paolo Carloni (SISSA, Trieste)
Julian Chela-Flores (ICTP, Trieste)



PROGRAMME:



                            FIRST WEEK

Monday, 16 March 1998


08:30 - 09:30           REGISTRATION

09:30 - 10:00   Opening Session


Chairperson:  Sandor Pongor


10:00 - 11:00                           E. Morton Bradbury
                                        Los Alamos National Laboratory, New Mexico
                                        Opening Lecture
                                        "The Human Genome and Unusual DNA
Structures"


11:00 - 11:30                           Break


11:30 - 12:30                           Adolfo Savoia
                                        Synchrotron, Trieste s.p.a.
                                        "Synchrotron Radiation in Structural Biology"


12:30 - 14:30                           Lunch


Chairperson: Paolo Carloni


14:30 - 15:30                           Stanley Opella
                                        University of Pennsylvania, Philadelphia
                                        "Solid State NMR of Membrane Proteins"


15:30 - 16:00                           Break


16:00 - 17:00                           Lucia Banci
                                        Universitá di Firenze
                                        "NMR, Metalloproteins"


18:00 -                         Small Reception



Tuesday, 17 March 1998


Chairperson: Doriano Lamba


09:00 - 10:00                           Vincent Torre
                                        SISSA, Trieste
                                        "Structure and Function of Ionic Channels"

10:00 - 11:00                           E. Morton Bradbury
                                        Los Alamos National Laboratory, New Mexico
                                       "Packaging of the Genome; Nucleosome and Chromatin Structures"



11:00 - 11:30                           Break


11:30 - 12:30                           Gilberto Vlaic
                                        Universitá di Trieste
                                        "EXAFS"


12:30 - 14:30                           Lunch


Chairperson: E. Morton Bradbury


14:30 - 15:30                           Gilberto Vlaic
                                        Universitá di Trieste
                                        "EXAFS"


15:30 - 16:00                           Break


16:00 - 17:00                           Lucia Banci
                                        Universitá di Firenze
                                        "NMR, Metalloproteins"

17:00 - 18:00                           Adolfo Savoia
                                        Synchrotron, Trieste s.p.a.
                                        "Synchrotron Radiation in Structural Biology"



Wednesday, 18 March 1998


Chairperson: Adolfo Savoia


09:00 - 10:00                           Peter Guentert
                                        ETH - Hoenggerberg, Zurich
                                        "Structure Determination of Biomacromolecules by NMR"

10:00 - 11:00                           Lucia Banci
                                        Universitá di Firenze
                                        "NMR, Metalloproteins"


11:00 - 11:30                           Break


11:30 - 12:30                           Peter Guentert
                                        ETH - Hoenggerberg, Zurich
                                        "Structure Determination of Biomacromolecules by NMR"


12:30 - 14:30                           Lunch


Chairperson: Peter Guentert



14:30 - 15:30                           Stanley Opella
                                        University of Pennsylvania, Philadelphia 
                                        "Solid StateNMR of Membrane Proteins"


15:30 - 16:00   Break


16:00 - 17:00                           Kalpathy R.K. Easwaran
                                        Indian Institute of Science, Bangalore
                                        "Lipid Microstructures and Structures of Cationic Lipid-DNA Complexes"



Thursday, 19 March 1998


Chairperson: Kalpathy R.K. Easwaran


09:00 - 10:00                           Kalpathy R.K. Easwaran
                                        Indian Institute of Science, Bangalore
                                        "Lipid Microstructures and Structures of Cationic Lipid-DNA Complexes"

10:00 - 11:00                           Anna Tramontano
                                        Istituto di Ricerche di Biologia Molecolare, Pomezia
                                        "Protein Modelling"



11:00 - 11:30                           Break


11:30 - 12:30                           Anna Tramontano
                                        Istituto di Ricerche di Biologia Molecolare, Pomezia
                                        "Protein Modelling"


12:30 - 14:30                           Lunch


Chairperson: Gilberto Vlaic


14:30 - 15:30                           Stanley Opella
                                        University of Pennsylvania, Philadelphia
                                        "Solid State NMR of Membrane Proteins"


15:30 - 16:00                           Break


16:00 - 17:00                           Gilberto Vlaic
                                        Universitá di Trieste
                                        "EXAFS"




Friday, 20 March 1998


Chairperson: Anna Tramontano



09:30 -10:30                            Kalpathy R.K. Easwaran
                                        Indian Institute of Science, Bangalore
                                        "Lipid Microstructures and Structures of Cationic Lipid-DNA Complexes"


10:30 - 11:00                           Break


11:00 - 12:00                           Istvan Simon
                                        Institute of Enzymology, Budapest
                                        "Protein Folding"


12:00 - 14:30                           Lunch


Chairperson:  Sandor Pongor


14:30 - 15:30                           Istvan Simon
                                        Institute of Enzymology, Budapest
                                        "Protein Folding"


15:30 - 16:00                           Break


16:00 - 17:00                           Anna Tramontano
                                        Istituto di Ricerche di Biologia Molecolare, Pomezia
                                        "Protein Modelling"







                                SECOND WEEK

Monday, 23 March 1998

Chairperson: G. Folkers

09:00 - 10:00                           Robert L. Baldwin
                                        Stanford University, California
                                        "Folding Intermediates and Folding
Pathway
                                          of Apomyoglobiin"

10:00 - 11:00                           Paolo Carloni
                                        SISSA, Trieste
                                        "ab Initio Molecular Dynamics of
Biological Systems"


11:00 - 11:30                           Break


11:30 - 12:30                           Gerd Folkers
                                        Eidgenössische Technische Hochschule, Zurich
                                       "Structure Based Design of Antivirals and Gene Therapy Tools"


12:30 - 14:30                           Lunch


Chairperson:  Istvan Simon


14:30 - 15:30                           Doriano Lamba
                                        CNR-ICGEB, Trieste
                                        "Principles of Biological Macromolecules Crystallisation"


15:30 - 17:00                           Round Table Discussion
                                        (Meeting Room - Behind Main Lecture
Hall)

                                        Coffee, Tea and Pastries will be served




Tuesday, 24 March 1998


Chairperson: Stefano Mangani


09:00 - 10:00                           Gerd Folkers
                                        Eidgenössische Technische Hochschule, Zurich
                                       "Structure Based Design of Antivirals and Gene Therapy Tools"

10:00 - 11:00                           Robert L. Baldwin
                                        Stanford University, California
                                        "Folding Intermediates and Folding Pathway of Apomyoglobiin"


11:00 - 11:30                           Break


11:30 - 12:30                           Gerd Folkers
                                        Eidgenössische Technische Hochschule, Zurich
                                       "Structure Based Design of Antivirals and Gene Therapy Tools"


12:30 - 14:30                           Lunch


Chairperson:   Robert L. Baldwin


14:30 - 15:30                           Stefano Mangani
                                        Universitá di Siena "Enzyme Mechanisms Through
                                        Crystallographic Research"


15:30 - 16:00                           Break


16:00 - 17:00                           Klaus J. Schulten
                                        University of Illinois, Beckman Institute, Urbana          
                                        "Structure and Function of a Protein Aggregate - the
                                        Light Harvesting Complexes of Purple Bacteria and
                                        their Organization in the Photosynthetic Apparatus"






Wednesday, 25 March 1998



Chairperson: Klaus J. Schulten


09:00 - 10:00                           Klaus J. Schulten
                                        University of Illinois, Beckman Institute, Urbana
                                        "Structure and Function of a Protein Aggregate - the
                                        Light Harvesting Complexes of Purple Bacteria and
                                        their Organization in the Photosynthetic Apparatus"


10:00 - 10:30                           Break


10:30 - 11:30                           Sandor Pongor
                                        ICGEB, Trieste
                                        "DNA Bending"

11:30 - 12:30                           Paolo Carloni
                                        SISSA, Trieste
                                        "ab Initio Molecular Dynamics of Biological Systems"


12:30 - 14:30                           Lunch


Chairperson: Doriano Lamba


14:30 - 15:30                           Robert L. Baldwin
                                        Stanford University, California
                                        "Folding Intermediates and Folding Pathway
                                        of Apomyoglobiin"


15:30 - 16:00                           Break


16:00 - 17:00                           Stefano Mangani
                                        Universitá di Siena "Enzyme Mechanisms Through
                                        Crystallographic Research"




Thursday, 26 March 1998

Chairperson: Paolo Carloni

Announcement of Winning Poster


09:00 - 10:00                           Carme Rovira
                                        Max-Planck-Institute, Stuttgart
                                        "Ab Initio Molecular Dynamics within
                                        The Car-Parrinello Approach"

10:00 - 11:00                           Carme Rovira
                                        Max-Planck-Institute, Stuttgart
                                        "Modelling of the Myoglobin Active
Site " (1)


11:00 - 11:30                           Break


11:30 - 12:30                           Doriano Lamba
                                        CNR-ICGEB, Trieste
                                        "Principles of Biological Macromolecules
                                        Crystallisation"


12:30 - 14:30                           Lunch


                                        No Lectures Scheduled



14:30 - 18:00                           To Participants concerned

                                        Visit to:

                                        ICGEB

                                          and

                                        Synchrotron Electtra





Friday, 27 March 1998


Chairperson: Sandor Pongor


09:00 - 10:00                           Sandor Pongor
                                        ICGEB, Trieste
                                        "DNA Bending"


10:00 - 11:00                           Jose-Maria Carazo
                                        University of Madrid
                                        "Image Analysis of Macromolecules"



11:00 - 11:30                           Break


11:30 - 12:30                           Jose-Maria Carazo
                                        University of Madrid
                                        "Image Analysis of Macromolecules"


12:30 - 14:30                           Lunch


Chairperson:  Jose-Maria Carazo


14:30 - 15:30                           Carme Rovira
                                        Max-Planck-Institute, Stuttgart
                                        "Modelling of the Myoglobin Active
Site " (2)


15:30 - 16:00                           Break


16:00 - 17:00                           3 Short "Oral" Poster Contributions
                                        (From Participants, selected by
Organizers)


17:00                                   Closing Address





CONTACT:

Ms. Valerie Shaw,
ICTP, Office 139, Strada Costiera 11, 34100 Trieste, Italy.
Tel: +39-40-22401 (ext. 541); Fax+39-40-224163;
E-mail: smr1098@ictp.trieste.it


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